Phenotypes associated with this allele

• Allele Symbol: Dnm1^tm1.2Frk
• Allele Name: targeted mutation 1.2, Wayne N Frankel
• Allele ID: MGI:5800540
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnm1^tm1.2Frk/Dnm1^tm1.2Frk	B6.129(Cg)-Dnm1^tm1.2Frk	MGI:5800563
ht2	Dnm1^Ftfl/Dnm1^tm1.2Frk	involves: 129 * C57BL/6J * FVB	MGI:5800565

Genotype
MGI:5800563

hm1

• Allelic Composition: Dnm1^tm1.2Frk/Dnm1^tm1.2Frk
• Genetic Background: B6.129(Cg)-Dnm1^tm1.2Frk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:235711 )

N • mice do not display spontaneous seizures and exhibit a normal electroconvulsive threshold

Genotype
MGI:5800565

ht2

• Allelic Composition: Dnm1^Ftfl/Dnm1^tm1.2Frk
• Genetic Background: involves: 129 * C57BL/6J * FVB

mortality/aging

premature death ( J:235711 )

• due to lethal seizures

nervous system

seizures ( J:235711 )

• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1^Ftfl heterozygotes (11 to 12 weeks)

• reduced electroconvulsive threshold compared with Dnm1^Ftfl heterozygotes

abnormal interictal brain wave pattern ( J:235711 )

• abnormal interictal EEG patterns with episodes of epileptiform spikes

behavior/neurological

seizures ( J:235711 )

• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1^Ftfl heterozygotes (11 to 12 weeks)

• reduced electroconvulsive threshold compared with Dnm1^Ftfl heterozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
generalized epilepsy		DOID:1827	OMIM:600669	J:235711