Phenotypes associated with this allele

• Allele Symbol: Ddx60^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5792890
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddx60^tm1b(EUCOMM)Wtsi/Ddx60^tm1b(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5903063
cx2	Ddx60^tm1b(EUCOMM)Wtsi/Ddx60^tm1b(EUCOMM)Wtsi Mavs^tm1Tsse/Mavs^tm1Tsse	involves: 129 * C57BL/6N	MGI:5903064

Genotype
MGI:5903063

hm1

• Allelic Composition: Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0327_7_A05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• after VSV infection

immune system

increased circulating interferon-alpha level ( J:228452 )

• after VSV infection

decreased circulating interferon-beta level ( J:228452 )

• after HCV RNA hydrodynamic injection

increased susceptibility to Riboviria infection ( J:228452 )

• after VSV infection, mice exhibit increased serum IFN-alpha levels, viral titers in the brain and mortality compared with wild-type mice

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• after VSV infection

homeostasis/metabolism

increased circulating interferon-alpha level ( J:228452 )

• after VSV infection

decreased circulating interferon-beta level ( J:228452 )

• after HCV RNA hydrodynamic injection

Genotype
MGI:5903064

cx2

• Allelic Composition: Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi}; Mavs^tm1Tsse/Mavs^tm1Tsse
• Genetic Background: involves: 129 * C57BL/6N
• Cell Lines: EPD0327_7_A05

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• more so than in Ddx60^{tm1b(EUCOMM)Wtsi} homozygotes after VSV infection

immune system

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• more so than in Ddx60^{tm1b(EUCOMM)Wtsi} homozygotes after VSV infection