All Phenotypes Ddx60<tm1b(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ddx60^{tm1b(EUCOMM)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5792890

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5903063
cx2	Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi} Mavs^tm1Tsse/Mavs^tm1Tsse	involves: 129 * C57BL/6N	MGI:5903064

Allelic Composition	Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0327_7_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx60^{tm1b(EUCOMM)Wtsi} mutation (0 available); any Ddx60 mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• after VSV infection

immune system

increased circulating interferon-alpha level ( J:228452 )

• after VSV infection

decreased circulating interferon-beta level ( J:228452 )

• after HCV RNA hydrodynamic injection

increased susceptibility to Riboviria infection ( J:228452 )

• after VSV infection, mice exhibit increased serum IFN-alpha levels, viral titers in the brain and mortality compared with wild-type mice

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• after VSV infection

homeostasis/metabolism

increased circulating interferon-alpha level ( J:228452 )

• after VSV infection

decreased circulating interferon-beta level ( J:228452 )

• after HCV RNA hydrodynamic injection

Allelic Composition	Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi} Mavs^tm1Tsse/Mavs^tm1Tsse
Genetic Background	involves: 129 * C57BL/6N
Cell Lines	EPD0327_7_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx60^{tm1b(EUCOMM)Wtsi} mutation (0 available); any Ddx60 mutation (98 available)
Mavs^tm1Tsse mutation (1 available); any Mavs mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• more so than in Ddx60^{tm1b(EUCOMM)Wtsi} homozygotes after VSV infection

immune system

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• more so than in Ddx60^{tm1b(EUCOMM)Wtsi} homozygotes after VSV infection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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