Analysis Tools
mortality/aging
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• no homozygous offspring are produced suggesting lethality during embryogenesis
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Allele Symbol Allele Name Allele ID |
Sgcdtm1Ojml targeted mutation 1, Oliver J Muller MGI:5792156 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygous offspring are produced suggesting lethality during embryogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show increased heart to body weight ratio
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• 1 year old mice develop a mild dilated cardiomyopathy phenotype after voluntary wheel running
• however, under baseline conditions, 1 year old hearts do not show histological signs of dilated cardiomyopathy such as cell degeneration, necrosis and fibrosis and echocardiography shows no differences in fractional shortening and preserved left ventricular function
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• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show reduced cumulative running distance over a period of 4 weeks from the age of 52 weeks
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• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show reduced cumulative running distance over a period of 4 weeks from the age of 52 weeks
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• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show reduced cumulative running distance and increased heart to body weight ratio indicating mild cardiomyopathy
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• 1 year old mice develop a mild dilated cardiomyopathy phenotype after voluntary wheel running
• however, under baseline conditions, 1 year old hearts do not show histological signs of dilated cardiomyopathy such as cell degeneration, necrosis and fibrosis and echocardiography shows no differences in fractional shortening and preserved left ventricular function
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• 10 month old mice exercised for 22 weeks using a voluntary wheel running system show increased heart to body weight ratio
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy 1L | DOID:0110436 |
OMIM:606685 |
J:234761 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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