Phenotypes associated with this allele

• Allele Symbol: Cd82^tm1.1Xaz
• Allele Name: targeted mutation 1.1, Xin A Zhang
• Allele ID: MGI:5790985
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd82^tm1.1Xaz/Cd82^tm1.1Xaz	B6NCr.Cg-Cd82^tm1.1Xaz	MGI:5791908
hm2	Cd82^tm1.1Xaz/Cd82^tm1.1Xaz	Not Specified	MGI:7312067

Genotype
MGI:5791908

hm1

• Allelic Composition: Cd82^tm1.1Xaz/Cd82^tm1.1Xaz
• Genetic Background: B6NCr.Cg-Cd82^tm1.1Xaz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal induced retina neovascularization ( J:234155 )

• high number and area of tuft formation following hypoxia and return to normoxia

abnormal tumor vascularization ( J:234155 )

• increased in implanted tumors

increased angiogenesis ( J:234155 )

• in a Matrigel plug angiogenesis assay with increased vascular area and microvessel density

• after 1 week in response to myocardial infarction

• ex vivo, aortic rings exhibit increased microvascular sprouting with increased length and area of sprouted vessels compared with wild-type mice

• however, lumen formation is proportional to more vasculature and retinal angiogenesis is normal

abnormal vascular endothelial cell migration ( J:234155 )

• increased migration toward chemoattractants, invasion into Matrigel and in vivo and increased penetration distance of endothelial cells from their coated beads in fibrin gel

abnormal response to cardiac infarction ( J:234155 )

• 1 week after myocardial infarction, mice exhibit increased angiogenesis compared with wild-type mice

cellular

abnormal vascular endothelial cell migration ( J:234155 )

• increased migration toward chemoattractants, invasion into Matrigel and in vivo and increased penetration distance of endothelial cells from their coated beads in fibrin gel

homeostasis/metabolism

abnormal response to cardiac infarction ( J:234155 )

• 1 week after myocardial infarction, mice exhibit increased angiogenesis compared with wild-type mice

neoplasm

abnormal tumor vascularization ( J:234155 )

• increased in implanted tumors

vision/eye

abnormal induced retina neovascularization ( J:234155 )

• high number and area of tuft formation following hypoxia and return to normoxia

Genotype
MGI:7312067

hm2

• Allelic Composition: Cd82^tm1.1Xaz/Cd82^tm1.1Xaz
• Genetic Background: Not Specified

immune system

abnormal macrophage differentiation ( J:326451 )

• activated bone marrow-derived macrophages fail to exhibit M1 phenotypes whereas M2 macrophages exhibit increased spreading compared with wild-type cell

abnormal cellular extravasation ( J:326451 )

• leukocyte adhering to and emigrating from the vasculature is increased compared to in wild-type mice

impaired leukocyte tethering or rolling ( J:326451 )

• after exposure to CXCL1

increased neutrophil cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model

increased macrophage cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model and in response to oxygen-induced retinopathy

abnormal neutrophil physiology ( J:326451 )

• increased neutrophil migration in response to CXCL1 or LTB4

increased susceptibility to bacterial infection ( J:326451 )

• L. Mexicana-infected mice exhibit increased infiltration of myeloid cells and increased size and persistence of lesions that persist longer than 11 weeks compared with wild-type mice

vision/eye

increased susceptilbility to retina ischemic injury ( J:326451 )

• increased myeloid cell migration and retinal inflammation in response to oxygen-induced retinopathy

hematopoietic system

abnormal macrophage differentiation ( J:326451 )

• activated bone marrow-derived macrophages fail to exhibit M1 phenotypes whereas M2 macrophages exhibit increased spreading compared with wild-type cell

abnormal cellular extravasation ( J:326451 )

• leukocyte adhering to and emigrating from the vasculature is increased compared to in wild-type mice

impaired leukocyte tethering or rolling ( J:326451 )

• after exposure to CXCL1

increased neutrophil cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model

increased macrophage cell number ( J:326451 )

• in a thioglycolate-induced peritonitis model and in response to oxygen-induced retinopathy

abnormal neutrophil physiology ( J:326451 )

• increased neutrophil migration in response to CXCL1 or LTB4

homeostasis/metabolism

increased susceptilbility to retina ischemic injury ( J:326451 )

• increased myeloid cell migration and retinal inflammation in response to oxygen-induced retinopathy

cellular

abnormal macrophage differentiation ( J:326451 )

• activated bone marrow-derived macrophages fail to exhibit M1 phenotypes whereas M2 macrophages exhibit increased spreading compared with wild-type cell

abnormal cellular extravasation ( J:326451 )

• leukocyte adhering to and emigrating from the vasculature is increased compared to in wild-type mice

impaired leukocyte tethering or rolling ( J:326451 )

• after exposure to CXCL1