Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-HTRA2)1Olri
• Allele Name: transgene insertion 1, Olaf Riess
• Allele ID: MGI:5790704
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp-HTRA2)1Olri/0	involves: C57BL/6	MGI:5790712

Genotype
MGI:5790712

tg1

• Allelic Composition: Tg(Prnp-HTRA2)1Olri/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor learning ( J:229160 )

• mice exhibit decreased motor skill learning

impaired balance ( J:229160 )

• mice exhibit an increase in the number of slips while traversing a mesh beam, indicating impaired balance and coordination

impaired coordination ( J:229160 )

• mice perform worse on the rotarod than wild-type mice or Tg(Prnp-HTRA2*G399S)1Olri mice from 6 months of age

cellular

abnormal cell physiology ( J:229160 )

• increase in steady-state levels of heat shock protein 60, total ubiquitin and XIAP, indicating a cellular stress response

abnormal mitochondrial physiology ( J:229160 )

• mitochondria consume less oxygen in response to ADP (lower state III respiration) and in response to the uncoupler carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (maximal respiration) compared to wild-type mice, resulting in lower spare respiratory capacity

• reduction of Complex I activity

• mitochondrial membrane potential in cells isolated from brains is about 35% lower than in wild-type mice, although this is not statistically significant

nervous system

abnormal cerebellum morphology ( J:229160 )

• about 50% increase in the amount of cell death in the cerebellum

loss of dopaminergic neurons ( J:229160 )

• mice exhibit a reduction of tyrosine hydroxylase+ neurons (dopaminergic neurons)