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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlklm2Btlr
mutation 2, Bruce Beutler
MGI:5789564
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mlklm2Btlr/Mlklm2Btlr C57BL/6J-Mlklm2Btlr MGI:5789632
ht2
 		Mlklm2Btlr/Mlkl+ C57BL/6J-Mlklm2Btlr MGI:5789633


Genotype
MGI:5789632
hm1
Allelic
Composition		 Mlklm2Btlr/Mlklm2Btlr
Genetic
Background		 C57BL/6J-Mlklm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlklm2Btlr mutation (0 available); any Mlkl mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:234252 )
• mice exhibited resistance to lipopolysaccharide (LPS)-induced necroptosis

cellular
decreased cell death ( J:234252 )
• mice exhibited resistance to lipopolysaccharide (LPS)-induced necroptosis




Genotype
MGI:5789633
ht2
Allelic
Composition		 Mlklm2Btlr/Mlkl+
Genetic
Background		 C57BL/6J-Mlklm2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlklm2Btlr mutation (0 available); any Mlkl mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:234252 )
• mice exhibited slight resistance to lipopolysaccharide (LPS)-induced necroptosis

cellular
decreased cell death ( J:234252 )
• mice exhibited slight resistance to lipopolysaccharide (LPS)-induced necroptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory