All Phenotypes Dock8<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dock8^m1Btlr
mutation 1, Bruce Beutler
MGI:5789558

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock8^m1Btlr/Dock8^m1Btlr	C57BL/6J-Dock8^m1Btlr	MGI:5789618

Allelic Composition	Dock8^m1Btlr/Dock8^m1Btlr
Genetic Background	C57BL/6J-Dock8^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8^m1Btlr mutation (0 available); any Dock8 mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgG level ( J:234247 )

• mice exhibited a diminished T-dependent antibody (IgG) response to ovalbumin administered with aluminum hydroxide (OVA/alum)

impaired humoral immune response ( J:234247 )

• mice exhibited a diminished T-dependent antibody (IgG) response to ovalbumin administered with aluminum hydroxide (OVA/alum)

hematopoietic system

decreased IgG level ( J:234247 )

• mice exhibited a diminished T-dependent antibody (IgG) response to ovalbumin administered with aluminum hydroxide (OVA/alum)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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