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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr4Lps-8Btlr
defective lipopolysaccharide response 8 Bruce Beutler
MGI:5789549
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr4Lps-8Btlr/Tlr4Lps-8Btlr C57BL/6J-Tlr4Lps-8Btlr MGI:5789774
ht2
 		Tlr4Lps-8Btlr/Tlr4+ C57BL/6J-Tlr4Lps-8Btlr MGI:5789775


Genotype
MGI:5789774
hm1
Allelic
Composition		 Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
Genetic
Background		 C57BL/6J-Tlr4Lps-8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4Lps-8Btlr mutation (0 available); any Tlr4 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:234241 )
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
decreased interleukin-1 beta secretion ( J:234241 )
• some mice also exhibited attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1 in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment
decreased tumor necrosis factor secretion ( J:234241 )
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

cellular
cellular necrosis ( J:234241 )
• mice showed resistance to LPS-induced macrophage necroptosis
increased cell death ( J:234241 )
• mice showed resistance to LPS-induced macrophage necroptosis

hematopoietic system
decreased macrophage cytokine production ( J:234241 )
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)




Genotype
MGI:5789775
ht2
Allelic
Composition		 Tlr4Lps-8Btlr/Tlr4+
Genetic
Background		 C57BL/6J-Tlr4Lps-8Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4Lps-8Btlr mutation (0 available); any Tlr4 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:234241 )
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)
decreased interleukin-1 beta secretion ( J:234241 )
• some mice also exhibited attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin (IL)-1 in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment
decreased tumor necrosis factor secretion ( J:234241 )
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

cellular
cellular necrosis ( J:234241 )
• mice showed resistance to LPS-induced macrophage necroptosis
increased cell death ( J:234241 )
• mice showed resistance to LPS-induced macrophage necroptosis

hematopoietic system
decreased macrophage cytokine production ( J:234241 )
• mice showed slight reduction in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory