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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Panx3tm1c(KOMP)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5788523
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Panx3tm1c(KOMP)Wtsi/Panx3tm1c(KOMP)Wtsi
Tg(Col2a1-cre)1Star/0 		involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N MGI:5788534


Genotype
MGI:5788534
cn1
Allelic
Composition		 Panx3tm1c(KOMP)Wtsi/Panx3tm1c(KOMP)Wtsi
Tg(Col2a1-cre)1Star/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx3tm1c(KOMP)Wtsi mutation (0 available); any Panx3 mutation (23 available)
Tg(Col2a1-cre)1Star mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased susceptibility to induced arthritis ( J:233542 )
• reduced severity and collagen staining in a DMM surgery model of induced osteoarthritis
osteophytes ( J:233542 )
• absent in a DMM surgery model of induced osteoarthritis

immune system
decreased susceptibility to induced arthritis ( J:233542 )
• reduced severity and collagen staining in a DMM surgery model of induced osteoarthritis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory