Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNFSF11)5519Edou mutation
(0 available)
Tnfsf11tles mutation
(2 available);
any
Tnfsf11 mutation
(30 available)
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normal phenotype
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• mice exhibit complete rescue of the abnormal phenotypes seen in single Tnfsf11tles homozygotes, including rescue of the osteopetrotic phenotype, of both lower and upper incisor eruption defects and of mesenteric lymph node organogenesis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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adipose tissue
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• progressive increase in adipocyte numbers in bone marrow that is apparent from the 3rd month of age
• increase in marrow adiposity is inversely correlated with bone marrow cellularity form 6 months of age
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skeleton
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• progressive increase in adipocyte numbers in bone marrow that is apparent from the 3rd month of age
• increase in marrow adiposity is inversely correlated with bone marrow cellularity form 6 months of age
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• increase in the number of giant osteoclasts at the epiphysis and the mid-diaphysis cortical region in 3 month old mice
• abundant osteoclasts are present within the cortical bone area
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• femoral length is modestly decreased in 3 month old mice
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• femurs show an increase in the bone marrow volume and the cortical total volume, indicating an increase in bone width
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• severe intracortical porosity at 3 months of age
• cortical porosity near growth plate is increased more than at mid-diaphysis
• progressive increase in cortical bone loss
• trabecularization of the cortical bone
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• 26% decrease in cortical bone volume
• 38% decrease in cortical bone volume fraction
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• 48% decrease in cortical thickness
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• trabecular bone loss is already seen by 4 weeks of age
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• almost complete absence of trabeculae by 3 months of age
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• severe bone loss that is already seen in the first month of age
• the metaphyseal regions of the distal femur and the proximal tibia are osteoporotic, showing an almost complete absence of trabeculae by 3 months of age
• treatment with denosumab, a human monoclonal antibody against human TNFSF11, inhibits bone resorption and reverses osteopporosis
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• accumulation of cartilaginous remnants mainly in the epiphysis of 4 week old mice and the metaphysis of 3 month old mice, which gradually disappear
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• cellular density in the resting/proliferation zones of growth plates is increased
• mice show a progressive growth plate loss, evident at 3 months of age, which almost disappears by 10 months
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• increased bone remodeling and trabecularization of the cortical bone
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• abundant osteoclasts are present within the cortical bone area, indicating increased cortical bone remodeling
• levels of serum TRACP-5b are increased in 3 month old mice, indicating active bone resorption
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• 70% reduction in stiffness of mid-diaphysis femurs from 3 month old mice
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• mid-diaphysis femurs from 3 month old mice show reduced biomechanical properties, with a 58% reduction in ultimate force, 70% reduction in stiffness, and 45% reduction in plastic energy
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hematopoietic system
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• increase in the number of giant osteoclasts at the epiphysis and the mid-diaphysis cortical region in 3 month old mice
• abundant osteoclasts are present within the cortical bone area
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homeostasis/metabolism
immune system
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• increase in the number of giant osteoclasts at the epiphysis and the mid-diaphysis cortical region in 3 month old mice
• abundant osteoclasts are present within the cortical bone area
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limbs/digits/tail
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• femoral length is modestly decreased in 3 month old mice
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• femurs show an increase in the bone marrow volume and the cortical total volume, indicating an increase in bone width
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