Phenotypes associated with this allele

• Allele Symbol: Or8a1^{tm40(Gnas*)Mom}
• Allele Name: targeted mutation 40, Peter Mombaerts
• Allele ID: MGI:5788006
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or8a1^tm40(Gnas*)Mom/Or8a1^tm40(Gnas*)Mom	B6;129P2-Or8a1^tm40(Gnas*)Mom/MomJ	MGI:5788566
ht2	Or8a1^tm27Mom/Or8a1^tm40(Gnas*)Mom	involves: 129P2/OlaHsd * C57BL/6	MGI:5788570

Genotype
MGI:5788566

hm1

• Allelic Composition: Or8a1^{tm40(Gnas*)Mom}/Or8a1^{tm40(Gnas*)Mom}
• Genetic Background: B6;129P2-Or8a1^{tm40(Gnas*)Mom}/MomJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:233447 )

• 20 of 36 olfactory bulbs showed disrupted glomerular formation while the other 16 had GFP+ glomerular formation in the correct position.

Genotype
MGI:5788570

ht2

• Allelic Composition: Or8a1^tm27Mom/Or8a1^{tm40(Gnas*)Mom}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal olfactory bulb morphology ( J:233447 )

• the RFP+ axons form compartmentalized glomeruli distinct from those formed by the GFP+ axons co-expressing constitutively active GNAS, indicating a changed axonal identity through expression of constitutively active GNAS