Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp5tm1.1(cre)Pfl mutation
(0 available);
any
Aqp5 mutation
(16 available)
Atp1b1tm1.1Zboro mutation
(1 available);
any
Atp1b1 mutation
(20 available)
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respiratory system
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N |
• lung permeability, wet-to-dry lung weight rations and lung morphology are similar to controls
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• 43% reduction in alveolar fluid clearance as compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1b1tm1.1Zboro mutation
(1 available);
any
Atp1b1 mutation
(20 available)
Tg(Nkx2-1-cre)2Sand mutation
(2 available)
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mortality/aging
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• pups die at 2-3 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1b1tm1.1Zboro mutation
(1 available);
any
Atp1b1 mutation
(20 available)
Tg(Sftpc-cre)1Blh mutation
(0 available)
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respiratory system
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N |
• lung permeability, wet-to-dry lung weight rations and lung morphology are similar to controls
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• 78% reduction in alveolar fluid clearance as compared to controls
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• IEQ (equivalent short circuit current) is reduced in cultured alveolar epithelial cell monolayers as compared to controls, however, RT (transepithelial electrical resistance) is similar to controls
• cultured alveolar epithelial cell monolayers exhibit lower unidirectional Na+ flux in the apical-to-basolateral direction and unchanged Na+ flux in the basolateral-to-apical direction as compared to controls
• baseline net Na+ absorption is lower than in control monolayers
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Analysis Tools