All Phenotypes Atp1b1<tm1.1Zboro> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp1b1^tm1.1Zboro
targeted mutation 1.1, Zea Borok
MGI:5787934

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aqp5^{tm1.1(cre)Pfl}/? Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro	129S-Atp1b1^tm1.1Zboro Aqp5^{tm1.1(cre)Pfl}	MGI:5788090
cn2	Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Nkx2-1-cre)2Sand/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5788016
cn3	Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Sftpc-cre)1Blh/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5788091

Allelic Composition	Aqp5^{tm1.1(cre)Pfl}/? Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro
Genetic Background	129S-Atp1b1^tm1.1Zboro Aqp5^{tm1.1(cre)Pfl}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp5^{tm1.1(cre)Pfl} mutation (0 available); any Aqp5 mutation (21 available)
Atp1b1^tm1.1Zboro mutation (1 available); any Atp1b1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired pulmonary alveolar fluid clearance ( J:233742 )

• 43% reduction in alveolar fluid clearance as compared to controls

respiratory system

respiratory system phenotype ( J:233742 )

N	• lung permeability, wet-to-dry lung weight rations and lung morphology are similar to controls

impaired pulmonary alveolar fluid clearance ( J:233742 )

• 43% reduction in alveolar fluid clearance as compared to controls

Allelic Composition	Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Nkx2-1-cre)2Sand/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1b1^tm1.1Zboro mutation (1 available); any Atp1b1 mutation (20 available)
Tg(Nkx2-1-cre)2Sand mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:233742 )

• pups die at 2-3 weeks of age

Allelic Composition	Atp1b1^tm1.1Zboro/Atp1b1^tm1.1Zboro Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1b1^tm1.1Zboro mutation (1 available); any Atp1b1 mutation (20 available)
Tg(Sftpc-cre)1Blh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired pulmonary alveolar fluid clearance ( J:233742 )

• 78% reduction in alveolar fluid clearance as compared to controls

respiratory system

respiratory system phenotype ( J:233742 )

N	• lung permeability, wet-to-dry lung weight ratios and lung morphology are similar to controls

impaired pulmonary alveolar fluid clearance ( J:233742 )

• 78% reduction in alveolar fluid clearance as compared to controls

abnormal respiratory epithelial sodium ion transmembrane transport ( J:233742 )

• IEQ (equivalent short circuit current) is reduced in cultured alveolar epithelial cell monolayers as compared to controls, however, RT (transepithelial electrical resistance) is similar to controls

• cultured alveolar epithelial cell monolayers exhibit lower unidirectional Na+ flux in the apical-to-basolateral direction and unchanged Na+ flux in the basolateral-to-apical direction as compared to controls

• baseline net Na+ absorption is lower than in control monolayers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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