Phenotypes associated with this allele

• Allele Symbol: Atg12^tm1.1Jdth
• Allele Name: targeted mutation 1.1, Jayanta Debnath
• Allele ID: MGI:5784706
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atg12^tm1.1Jdth/Atg12^tm1.1Jdth	involves: C57BL/6	MGI:5784714
cn2	Atg12^tm1.1Jdth/Atg12^tm1.1Jdth Tg(Pomc1-cre)1Gsb/0	involves: C57BL/6 * FVB/N	MGI:5784715

Genotype
MGI:5784714

hm1

• Allelic Composition: Atg12^tm1.1Jdth/Atg12^tm1.1Jdth
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:232686 )

• all mice die rapidly on P1

Genotype
MGI:5784715

cn2

• Allelic Composition: Atg12^tm1.1Jdth/Atg12^tm1.1Jdth; Tg(Pomc1-cre)1Gsb/0
• Genetic Background: involves: C57BL/6 * FVB/N

growth/size/body

growth/size/body region phenotype ( J:232686 )

N • mice fed standard chow exhibit normal body weight, lean mass and body length

N • mice fed a high-fat diet exhibit normal lean mass and body length

increased body fat mass ( J:232686 )

• in mice fed a high-fat diet

increased body weight ( J:232686 )

• in mice fed a high-fat diet

increased susceptibility to diet-induced obesity ( J:232686 )

• in mice fed a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:232686 )

N • mice fed a high-fat diet exhibit normal insulin resistance, oxygen consumption and carbon dioxide elimination

abnormal autophagy ( J:232686 )

• complete loss of autophagy in hypothalamus neurons whether mice are fed a normal or high-fat diet

increased susceptibility to diet-induced obesity ( J:232686 )

• in mice fed a high-fat diet

impaired glucose tolerance ( J:232686 )

• in mice fed a high-fat diet

adipose tissue

adipose tissue phenotype ( J:232686 )

N • mice fed a normal diet exhibit normal fat mass and adiposity

increased total body fat amount ( J:232686 )

• in mice fed a high-fat diet

increased body fat mass ( J:232686 )

• in mice fed a high-fat diet

behavior/neurological

increased food intake ( J:232686 )

• in mice fed a high-fat diet

decreased locomotor activity ( J:232686 )

• in mice fed a high-fat diet during the dark cycle

cellular

abnormal autophagy ( J:232686 )

• complete loss of autophagy in hypothalamus neurons whether mice are fed a normal or high-fat diet

nervous system

nervous system phenotype ( J:232686 )

N • mice exhibit normal POMC neuron numbers and corticotroph function

skeleton

skeleton phenotype ( J:232686 )

N • mice fed a high-fat or normal diet exhibit normal bone mineral density