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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapre3tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5780100
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapre3tm1c(EUCOMM)Wtsi/Mapre3tm1c(EUCOMM)Wtsi
Tg(Tek-icre/ERT2)1Soff/0 		involves: C57BL/6N * FVB/N MGI:5780104


Genotype
MGI:5780104
cn1
Allelic
Composition		 Mapre3tm1c(EUCOMM)Wtsi/Mapre3tm1c(EUCOMM)Wtsi
Tg(Tek-icre/ERT2)1Soff/0
Genetic
Background		 involves: C57BL/6N * FVB/N
Cell Lines EPD0144_4_G05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapre3tm1c(EUCOMM)Wtsi mutation (0 available); any Mapre3 mutation (17 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular permeability ( J:224855 )
• after infusion with a peptide agonist of PAR-1 (F2r), lung vasculature fails to exhibit hyper-permeability unlike in wild-type mice
• however, untreated mice exhibit normal adult microvasculature in the lungs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory