Phenotypes associated with this allele

• Allele Symbol: Tmx2^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5779820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmx2^tm1.1(KOMP)Vlcg/Tmx2^tm1.1(KOMP)Vlcg	B6N(Cg)-Tmx2^tm1.1(KOMP)Vlcg/2J	MGI:6376186
hm2	Tmx2^tm1.1(KOMP)Vlcg/Tmx2^tm1.1(KOMP)Vlcg	C57BL/6N-Tmx2^tm1.1(KOMP)Vlcg/J	MGI:6263731

Genotype
MGI:6376186

hm1

• Allelic Composition: Tmx2^{tm1.1(KOMP)Vlcg}/Tmx2^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Tmx2^{tm1.1(KOMP)Vlcg}/2J
• Cell Lines: 10209A-A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at slightly lower Mendelian ratios at E3.5 (20% versus expected 25%) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

embryo

failure of blastocyst formation ( J:279207 )

• embryos fail to reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in culture, embryos fail to hatch from the zona pellucida with apparent cell death, never reaching a morphological blastocyst stage

abnormal morula morphology ( J:279207 )

• morulas recovered at E3.5 appear to be dying

cellular

increased cell death ( J:279207 )

• morulas recovered at E3.5 appear to be dying

• embryos show no further development with apparent cell death after 3 days in culture

Genotype
MGI:6263731

hm2

• Allelic Composition: Tmx2^{tm1.1(KOMP)Vlcg}/Tmx2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Tmx2^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 10209A-A10

Data Sources

IMPC Data for Tmx2

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX