Phenotypes associated with this allele

• Allele Symbol: Rasal3^tm1.1Fuj
• Allele Name: targeted mutation 1.1, Masahiro Fujii
• Allele ID: MGI:5776708
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasal3^tm1.1Fuj/Rasal3^tm1.1Fuj	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:5776709

Genotype
MGI:5776709

hm1

• Allelic Composition: Rasal3^tm1.1Fuj/Rasal3^tm1.1Fuj
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased granulocyte number ( J:229641 )

• in the bone marrow

decreased NK T cell number ( J:229641 )

• in the liver not spleen

• however, thymic NKT development is normal

decreased circulating interferon-gamma level ( J:229641 )

• alpha-GalCer-induced

decreased circulating interleukin-4 level ( J:229641 )

• alpha-GalCer-induced

decreased interferon-gamma secretion ( J:229641 )

• in alpha-GalCer-treated NKT cells

decreased interleukin-4 secretion ( J:229641 )

• in alpha-GalCer-treated NKT cells

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:229641 )

• alpha-GalCer-induced

decreased circulating interleukin-4 level ( J:229641 )

• alpha-GalCer-induced

decreased circulating alanine transaminase level ( J:229641 )

• in mice treated with alpha-GalCer

decreased circulating aspartate transaminase level ( J:229641 )

• in mice treated with alpha-GalCer

decreased susceptibility to injury ( J:229641 )

• decreased liver injury induced by alpha-GalCer with fewer necrotic spots

hematopoietic system

increased granulocyte number ( J:229641 )

• in the bone marrow

decreased NK T cell number ( J:229641 )

• in the liver not spleen

• however, thymic NKT development is normal