All Phenotypes Atp6ap2<tm1.1Ics> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp6ap2^tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5776594

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atp6ap2^tm1.1Ics/Y	involves: C57BL/6 * C57BL/6N	MGI:5779964
cn2	Atp6ap2^tm1.1Ics/Y Tg(NPHS2-cre)295Lbh/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:5779963

Allelic Composition	Atp6ap2^tm1.1Ics/Y
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2^tm1.1Ics mutation (1 available); any Atp6ap2 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:232697 )

• impaired in podocytes infected with a cre-expressing adenovirus

homeostasis/metabolism

impaired autophagy ( J:232697 )

• impaired in podocytes infected with a cre-expressing adenovirus

Allelic Composition	Atp6ap2^tm1.1Ics/Y Tg(NPHS2-cre)295Lbh/0
Genetic Background	involves: C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2^tm1.1Ics mutation (1 available); any Atp6ap2 mutation (11 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:232697 )

• between 2 and 3 weeks after birth

renal/urinary system

increased podocyte apoptosis ( J:232697 )

increased urine protein level ( J:232697 )

• by 14 days

albuminuria ( J:232697 )

• at P2

abnormal podocyte morphology ( J:232697 )

• impaired vacuolar acidification with abnormal cytoskeleton organization and cell death

podocyte foot process effacement ( J:232697 )

abnormal renal tubule epithelium morphology ( J:232697 )

• massive protein enrichment

absent proximal convoluted tubule brush border ( J:232697 )

dilated renal tubule ( J:232697 )

renal cast ( J:232697 )

• protein casts in renal tubules

homeostasis/metabolism

impaired autophagy ( J:232697 )

• impaired in podocytes

increased circulating creatinine level ( J:232697 )

• by 14 days

increased circulating cholesterol level ( J:232697 )

• by 14 days

decreased circulating serum albumin level ( J:232697 )

• by 14 days

increased blood urea nitrogen level ( J:232697 )

• by 14 days

increased urine protein level ( J:232697 )

• by 14 days

albuminuria ( J:232697 )

• at P2

cellular

abnormal cell cytoskeleton morphology ( J:232697 )

• impaired vacuolar acidification with abnormal cytoskeleton organization and cell death

impaired autophagy ( J:232697 )

• impaired in podocytes

increased podocyte apoptosis ( J:232697 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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