Phenotypes associated with this allele

• Allele Symbol: Tg(Phox2b-EGFP)JX99Gsat
• Allele Name: transgene insertion JX99, GENSAT Project at Rockefeller University
• Allele ID: MGI:5776545
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gpr4^tm1Mglg/Gpr4^tm1Mglg Tg(Phox2b-EGFP)JX99Gsat/0	either: (involves: BALB/c * FVB/NTac) or (involves: BALB/c * C57BL/6J * FVB/NTac)	MGI:5776707

Genotype
MGI:5776707

cx1

• Allelic Composition: Gpr4^tm1Mglg/Gpr4^tm1Mglg; Tg(Phox2b-EGFP)JX99Gsat/0
• Genetic Background: either: (involves: BALB/c * FVB/NTac) or (involves: BALB/c * C57BL/6J * FVB/NTac)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nerve fiber response ( J:224758 )

• many retrotrapezoid nucleus (RTN) neurons are pH-insensitive and those that remain pH-sensitive exhibit lower firing rates across a pH range compared with control cells

• under voltage clamp, the pH-dependent background potassium current is absent unlike in control cells

• when dialyzed with GTP-gamma-S, RTN neurons exhibit diminished membrane potential with repeated pH changes unlike wild-type cells