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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fustm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5776262
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fustm1c(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi involves: C3H * C57BL/6 * C57BL/6N MGI:5823863
cn2
 		Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Mapttm3.1(FUS)Neas/Mapt+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129 * C3H * C57BL/6 * C57BL/6N MGI:5824116
cn3
 		Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Chattm2(cre)Lowl/Chat+ 		involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N MGI:5823868
cn4
 		Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129S/SvEv * C3H * C57BL/6 * C57BL/6N MGI:5824114


Genotype
MGI:5823863
hm1
Allelic
Composition		 Fustm1c(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6N
Cell Lines EPD0667_5_C04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fustm1c(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:232167 )
• mice exhibit normal postnatal survival




Genotype
MGI:5824116
cn2
Allelic
Composition		 Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Mapttm3.1(FUS)Neas/Mapt+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129 * C3H * C57BL/6 * C57BL/6N
Cell Lines EPD0667_5_C04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fustm1a(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
Fustm1c(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
Mapttm3.1(FUS)Neas mutation (0 available); any Mapt mutation (428 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:232167 )
• mice treated with tamoxifen postnatally show denervation in the tibialis anterior muscle where about 12% of neuromuscular junctions are denervated




Genotype
MGI:5823868
cn3
Allelic
Composition		 Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Chattm2(cre)Lowl/Chat+
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N
Cell Lines EPD0667_5_C04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm2(cre)Lowl mutation (4 available); any Chat mutation (57 available)
Fustm1a(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
Fustm1c(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:232167 )
N
• no motor neuron degeneration is seen up to 1 year of age




Genotype
MGI:5824114
cn4
Allelic
Composition		 Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * C3H * C57BL/6 * C57BL/6N
Cell Lines EPD0667_5_C04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fustm1a(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
Fustm1c(EUCOMM)Wtsi mutation (0 available); any Fus mutation (39 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:232167 )
N
• no significant loss of lumbar level 5 motor neurons or denervation of the tibialis anterior muscle are seen at P240




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory