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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mapttm2(FUS)Neas
targeted mutation 2, Neil A Shneider
MGI:5776260
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Chattm2(cre)Lowl/Chat+
Mapttm2(FUS)Neas/Mapt+
B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl MGI:5823845


Genotype
MGI:5823845
cn1
Allelic
Composition
Chattm2(cre)Lowl/Chat+
Mapttm2(FUS)Neas/Mapt+
Genetic
Background
B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm2(cre)Lowl mutation (4 available); any Chat mutation (57 available)
Mapttm2(FUS)Neas mutation (0 available); any Mapt mutation (428 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• motor neuron loss is seen at P60 but not P30, when 10% of lumbar level 5 (L5) motor neurons are lost and by P360, there are 18.6% fewer motor neurons overall in the L5 segment
• about 10% denervation of the tibialis anterior neuromuscular junctions (NMJs), first seen at P60 which progresses with age such that at P360, about 25% of NMJs are denervated
• denervation is first noted at P120 in the gastrocnemius muscle where about 10% of NMJs are denervated
• however, even at P360, no denervation is seen in the soleus muscle NMJs





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory