Phenotypes associated with this allele

• Allele Symbol: Sctr^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:5774826
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sctr^tm1Brd/Sctr^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5810673

Genotype
MGI:5810673

hm1

• Allelic Composition: Sctr^tm1Brd/Sctr^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:114853 )

• hippocampal CA1 pyramidal neurons show a significant reduction in the average spine number of apical dendrites relative to wild-type neurons

• however, no gross anatomical abnormalities are observed in brain

abnormal hippocampal pyramidal neuron dendrite morphology ( J:114853 )

• mice exhibit significantly fewer spines on hippocampal CA1 apical dendrites than wild-type controls

• however, the average number of apical and basilar dendritic branches in CA1 pyramidal neurons is normal

abnormal CNS synaptic transmission ( J:114853 )

• mice exhibit impaired postsynaptic transmission in the hippocampal CA1 region due to miscommunication across the Schaffer collateral synapse

• however, short-term synaptic plasticity is normal with no notable deficits in paired-pulse facilitation at any of the interpulse intervals tested

abnormal excitatory postsynaptic potential ( J:114853 )

• mice show an overall reduction in postsynaptic transmission at Schaffer collateral synapses due to a decrease in the slope of the pEPSP at increasing stimulus intensities

• however, fiber volley amplitude is not altered, suggesting that presynaptic terminal firing is normal

reduced long-term potentiation ( J:114853 )

• mice show a significant reduction in overall LTP induction immediately after high-frequency stimulation of the Schaffer collateral pathway in the CA1 area and throughout the LTP induction and maintenance phases

behavior/neurological

impaired spatial learning ( J:114853 )

• in the reversal hidden platform task of the Morris water maze test, mice fail to show a decrease in latency to locate a new platform position that is submerged and moved to the opposite quadrant over the 4 blocks of trials relative to wild-type controls

impaired coordination ( J:114853 )

• on the accelerating rotarod, mice perform significantly worse than wild-type controls during the last trials on the second day of training

increased locomotor activity ( J:114853 )

• in the open field test, mice move significantly faster than wild-type controls

• however, distance traveled, time spent moving, and rearing responses are not significantly altered

abnormal social/conspecific interaction behavior ( J:114853 )

• in the tube test of social dominance, mice win significantly more (81%) matches against wild-type littermates than expected by chance, indicating abnormal social behavior

abnormal social recognition ( J:114853 )

• in the partition test, mice show a significantly lower recognition ratio than wild-type controls during the test with unfamiliar partner, indicating impaired social recognition

• however, time near the partition during the familiar partner baseline test is not significantly altered