Phenotypes associated with this allele

• Allele Symbol: Wwp2^tm1.1Yyiw
• Allele Name: targeted mutation 1.1, Yan-Yi Wang
• Allele ID: MGI:5774713
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wwp2^tm1.1Yyiw/Wwp2^tm1.1Yyiw	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:5774717

Genotype
MGI:5774717

hm1

• Allelic Composition: Wwp2^tm1.1Yyiw/Wwp2^tm1.1Yyiw
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:228707 )

• pIpC-treated mice exhibit earlier death onset and higher percentage of lethality compared with wild-type mice

• however, lethality response to LPS is normal

immune system

immune system phenotype ( J:228707 )

N • mice exhibit normal immune cell development

increased circulating interferon-beta level ( J:228707 )

• in pIpC-treated mice

increased circulating interleukin-6 level ( J:228707 )

• in pIpC-treated mice

• however, LPS-induced levels are normal

increased circulating tumor necrosis factor level ( J:228707 )

• in pIpC-treated mice

• however, LPS-induced levels are normal

homeostasis/metabolism

increased circulating interferon-beta level ( J:228707 )

• in pIpC-treated mice

increased circulating interleukin-6 level ( J:228707 )

• in pIpC-treated mice

• however, LPS-induced levels are normal

increased circulating tumor necrosis factor level ( J:228707 )

• in pIpC-treated mice

• however, LPS-induced levels are normal

increased susceptibility to xenobiotic induced morbidity/mortality ( J:228707 )

• pIpC-treated mice exhibit earlier death onset and higher percentage of lethality compared with wild-type mice

• however, lethality response to LPS is normal