Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(T-cre)1Lwd mutation
(1 available)
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skeleton
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• 33% of mutants show fusion of ribs in the thoracic region
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• neonates show vertebral malformations with a higher penetrance at the cervical level than at thoracic and lumber regions
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• reduction in the number of thoracic vertebrae (12 instead of 13)
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• absence of the tuberculum anterior on C6
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• some mutants only have five lumbar vertebrae instead of six
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• cervical regions show malformed neural arches
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• neonates show vertebral fusions with a higher penetrance at the cervical level than at thoracic and lumber regions
• cervical vertebra 1 and associated anterior arch of the atlas are fused to the basioccipital bone
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• neonates show the presence of a high number of homeotic transformations
• C2/C3 are anteriorly transformed
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• cervical regions show anterior homeotic transformations
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Pax3-cre)1Joe mutation
(0 available)
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mortality/aging
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• a high number of newborns die at about P1, with very little, if any, milk in their stomach
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• a subset of mutants with severe growth delay die at around P10
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behavior/neurological
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• newborns that die at P1 have very little, if any, milk in their stomachs
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growth/size/body
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• mutants that survive past P2 exhibit severe growth delay
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integument
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• 100% of mice that survive past P2 show pigmentation anomalies
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• mice that survive past P2 lack pigmentation in the hindpaws
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• mice that survive past P2 lack pigmentation in the distal tail
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• in about 25% of surviving mice, a tiny white spot is seen on the belly
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limbs/digits/tail
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• half of newborns exhibit a kinked tail
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pigmentation
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• 100% of mice that survive past P2 show pigmentation anomalies
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• mice that survive past P2 lack pigmentation in the hindpaws
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• mice that survive past P2 lack pigmentation in the distal tail
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• in about 25% of surviving mice, a tiny white spot is seen on the belly
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renal/urinary system
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• about half of mice that die at P10 exhibit hydronephrotic kidney
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reproductive system
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• mice exhibit reproduction problems
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1tm1Pgr mutation
(1 available);
any
Cdx1 mutation
(13 available)
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Pax3-cre)1Joe mutation
(0 available)
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cellular
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• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants
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embryo
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• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants
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integument
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• increase in penetrance and extent of white spotting in the posterior regions
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nervous system
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• E10.5 mutants exhibit abnormalities of the hypoglossal nerve, with the converging roots appearing disorganized and less dense and resulting in a reduced number of elongating axons that are shorter
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• E10.5 embryos exhibit the presence of fusions of dorsal root ganglia in the cervical region
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pigmentation
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• increase in penetrance and extent of white spotting in the posterior regions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Pax3Sp mutation
(4 available);
any
Pax3 mutation
(50 available)
Tg(Pax3-cre)1Joe mutation
(0 available)
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integument
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• posterior pigmentation anomalies of each single mutant are accentuated in all double mutants
• lack of pigmentation in the forepaws and hindpaws
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• lack of pigmentation in the distal tail
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nervous system
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• mice exhibit hypoganglionosis
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pigmentation
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• posterior pigmentation anomalies of each single mutant are accentuated in all double mutants
• lack of pigmentation in the forepaws and hindpaws
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• lack of pigmentation in the distal tail
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Analysis Tools