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Allele Symbol Allele Name Allele ID |
Tg(Sox3-GFP,Tyr)HolNpln transgene insertion Hol, Nicolas Pilon MGI:5774447 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• colonic aganglionosis is caused by a cell-autonomous defect in enteric neural crest cell migration
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• colonic aganglionosis is caused by a cell-autonomous defect in enteric neural crest cell migration
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice do not survive beyond weaning
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• decreased enteric nerve system density in the mid-colon
• female and male mice are equally affected
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• lack of myenteric ganglia in the distal colon despite large extrinsic nerve fibers and isolated neurons
• however, ganglia are detected in the proximal colon
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• mice have a single pigmented patch on their back with otherwise white fur
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• dilatation of the proximal and mid-colon without myenteric ganglia in the distal colon
• however, ganglia are detected in the proximal colon
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• delayed gut colonization by enteric neural crest cells
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• delayed gut colonization by enteric neural crest cells
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• mice have a single pigmented patch on their back with otherwise white fur
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Hirschsprung's disease | DOID:10487 |
OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644 |
J:229828 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have a single large pigmented patch on their back with otherwise white fur
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• mice have a single large pigmented patch on their back with otherwise white fur
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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