Phenotypes associated with this allele

• Allele Symbol: Nabp2^tm1.1Schg
• Allele Name: targeted mutation 1.1, Sandy Chang
• Allele ID: MGI:5770469
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nabp2^tm1.1Schg/Nabp2^tm1.1Schg	involves: 129S7/SvEvBrd * C57BL/6	MGI:5770585

Genotype
MGI:5770585

hm1

• Allelic Composition: Nabp2^tm1.1Schg/Nabp2^tm1.1Schg
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:228558 )

• despite being viable at E13.5 to E17.5, all mice die by P0

cellular

abnormal telomere morphology ( J:228558 )

• increased number of telomere fragments, telomere duplication at chromatid arms and chromosome ends without telomere signals in mouse embryonic fibroblasts

• increase aberration in gamma-irradiated mouse embryonic fibroblasts

chromosomal instability ( J:228558 )

• 2-fold increase in aberrant chromosome in mouse embryonic fibroblasts

growth/size/body

decreased birth body size ( J:228558 )

limbs/digits/tail

abnormal hindlimb morphology ( J:228558 )

• at P0