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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nabp2tm1Schg
targeted mutation 1, Sandy Chang
MGI:5770467
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nabp2tm1Schg/Nabp2tm1Schg involves: 129S7/SvEvBrd * C57BL/6 MGI:5770580
cx2
 		Nabp2tm1Schg/Nabp2tm1Schg
Trp53tm1Brd/Trp53tm1Brd 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5770583


Genotype
MGI:5770580
hm1
Allelic
Composition		 Nabp2tm1Schg/Nabp2tm1Schg
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nabp2tm1Schg mutation (0 available); any Nabp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by gamma-irradiation ( J:228558 )
• in mouse embryonic fibroblasts
premature death ( J:228558 )
• median survival 8.6 months for males is and 13 months for females

hematopoietic system
increased spleen red pulp amount ( J:228558 )
• hyperplasia
• however, germinal center appearance is normal

cellular
chromosomal instability ( J:228558 )
• increased chromosomal aberrations in irradiated mouse embryonic fibroblasts

homeostasis/metabolism
increased mortality induced by gamma-irradiation ( J:228558 )
• in mouse embryonic fibroblasts

immune system
increased spleen red pulp amount ( J:228558 )
• hyperplasia
• however, germinal center appearance is normal




Genotype
MGI:5770583
cx2
Allelic
Composition		 Nabp2tm1Schg/Nabp2tm1Schg
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nabp2tm1Schg mutation (0 available); any Nabp2 mutation (16 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:228558 )
• disseminated lymphoma in the kidney and liver unlike in Trp53tm1Brd mice
• however, total cancer incidents are not elevated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory