About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem203tm1.1Roml
targeted mutation 1.1, Mark A Labow
MGI:5770432
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem203tm1.1Roml/Tmem203tm1.1Roml involves: C57BL/6 MGI:5770444


Genotype
MGI:5770444
hm1
Allelic
Composition		 Tmem203tm1.1Roml/Tmem203tm1.1Roml
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem203tm1.1Roml mutation (0 available); any Tmem203 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:222925 )
N
• male mice exhibit normal prostate gland, seminal vesicle, epididymides, serum testosterone, follicle stimulating hormone and luteinizing hormone
abnormal sperm head morphology ( J:222925 )
• abnormal shape
• however, sperm exhibit normal condensation of chromatin and morphology of the acrosome
abnormal testis morphology ( J:222925 )
• testicular cells exhibit altered calcium mobilization compared with wild-type cells
seminiferous tubule degeneration ( J:222925 )
• atrophy is occasionally observed
decreased testis weight ( J:222925 )
• at 24 weeks
abnormal spermiation ( J:222925 )
• arrested at the nuclear condensation stage
• however, meiosis is normal
reduced female fertility ( J:222925 )
• female mice produce fewer litters than wild-type mice

growth/size/body
decreased body weight ( J:222925 )

cellular
abnormal sperm head morphology ( J:222925 )
• abnormal shape
• however, sperm exhibit normal condensation of chromatin and morphology of the acrosome
abnormal endoplasmic reticulum physiology ( J:222925 )
• thapsigargin- or m-3mFBS-treated mouse embryonic fibroblasts exhibit reduced total calcium release from the endoplasmic reticulum compared with wild-type cells

endocrine/exocrine glands
abnormal testis morphology ( J:222925 )
• testicular cells exhibit altered calcium mobilization compared with wild-type cells
seminiferous tubule degeneration ( J:222925 )
• atrophy is occasionally observed
decreased testis weight ( J:222925 )
• at 24 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory