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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tmem203tm1.1Roml
targeted mutation 1.1, Mark A Labow
MGI:5770432
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tmem203tm1.1Roml/Tmem203tm1.1Roml involves: C57BL/6 MGI:5770444


Genotype
MGI:5770444
hm1
Allelic
Composition
Tmem203tm1.1Roml/Tmem203tm1.1Roml
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem203tm1.1Roml mutation (0 available); any Tmem203 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male mice exhibit normal prostate gland, seminal vesicle, epididymides, serum testosterone, follicle stimulating hormone and luteinizing hormone
• abnormal shape
• however, sperm exhibit normal condensation of chromatin and morphology of the acrosome
• testicular cells exhibit altered calcium mobilization compared with wild-type cells
• atrophy is occasionally observed
• at 24 weeks
• arrested at the nuclear condensation stage
• however, meiosis is normal
• female mice produce fewer litters than wild-type mice

growth/size/body

cellular
• abnormal shape
• however, sperm exhibit normal condensation of chromatin and morphology of the acrosome
• thapsigargin- or m-3mFBS-treated mouse embryonic fibroblasts exhibit reduced total calcium release from the endoplasmic reticulum compared with wild-type cells

endocrine/exocrine glands
• testicular cells exhibit altered calcium mobilization compared with wild-type cells
• atrophy is occasionally observed
• at 24 weeks





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory