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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Klhl40tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:5769997
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Klhl40tm1.1Itl/Klhl40tm1.1Itl involves: 129S6/SvEvTac * C57BL/6N MGI:5770002
cx2
 		E2f1tm1Njd/E2f1tm1Njd
Klhl40tm1.1Itl/Klhl40tm1.1Itl 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N MGI:5770003


Genotype
MGI:5770002
hm1
Allelic
Composition		 Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl40tm1.1Itl mutation (0 available); any Klhl40 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

muscle
abnormal sarcomere morphology ( J:227534 )
• abnormal with fewer mitochondria and increased extracellular matrix compared with wild-type sarcomeres

growth/size/body
decreased body size ( J:227534 )
slow postnatal weight gain ( J:227534 )
• mice fail to gain weight

cellular




Genotype
MGI:5770003
cx2
Allelic
Composition		 E2f1tm1Njd/E2f1tm1Njd
Klhl40tm1.1Itl/Klhl40tm1.1Itl
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Njd mutation (1 available); any E2f1 mutation (25 available)
Klhl40tm1.1Itl mutation (0 available); any Klhl40 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:227534 )
N
• mice are born viable and survive weaning

growth/size/body
decreased body size ( J:227534 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory