All Phenotypes Klhl40<tm1.1Itl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Klhl40^tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:5769997

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl40^tm1.1Itl/Klhl40^tm1.1Itl	involves: 129S6/SvEvTac * C57BL/6N	MGI:5770002
cx2	E2f1^tm1Njd/E2f1^tm1Njd Klhl40^tm1.1Itl/Klhl40^tm1.1Itl	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N	MGI:5770003

Allelic Composition	Klhl40^tm1.1Itl/Klhl40^tm1.1Itl
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl40^tm1.1Itl mutation (0 available); any Klhl40 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:227534 )

muscle

increased skeletal muscle cell apoptosis ( J:227534 )

abnormal sarcomere morphology ( J:227534 )

• abnormal with fewer mitochondria and increased extracellular matrix compared with wild-type sarcomeres

decreased skeletal muscle fiber size ( J:227534 )

growth/size/body

decreased body size ( J:227534 )

slow postnatal weight gain ( J:227534 )

• mice fail to gain weight

cellular

increased skeletal muscle cell apoptosis ( J:227534 )

Allelic Composition	E2f1^tm1Njd/E2f1^tm1Njd Klhl40^tm1.1Itl/Klhl40^tm1.1Itl
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1^tm1Njd mutation (1 available); any E2f1 mutation (28 available)
Klhl40^tm1.1Itl mutation (0 available); any Klhl40 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:227534 )

N	• mice are born viable and survive weaning

growth/size/body

decreased body size ( J:227534 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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