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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk4tm1b(NCOM)Mfgc
targeted mutation 1b, Mammalian Functional Genomics Centre
MGI:5766181
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp MGI:5797428
ht2
 		Cdk4tm1b(NCOM)Mfgc/Cdk4+ C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp MGI:5797427


Genotype
MGI:5797428
hm1
Allelic
Composition		 Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic
Background		 C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp
Cell Lines M00049_C_390W_F08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1b(NCOM)Mfgc mutation (1 available); any Cdk4 mutation (57 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

growth/size/body
abnormal embryo size ( J:211773 )
IMPC - TCP

homeostasis/metabolism
edema ( J:211773 )
IMPC - TCP

mortality/aging

reproductive system
male infertility ( J:211773 )
IMPC - TCP

vision/eye
microphthalmia ( J:211773 )
IMPC - TCP




Genotype
MGI:5797427
ht2
Allelic
Composition		 Cdk4tm1b(NCOM)Mfgc/Cdk4+
Genetic
Background		 C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp
Cell Lines M00049_C_390W_F08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1b(NCOM)Mfgc mutation (1 available); any Cdk4 mutation (57 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

growth/size/body
decreased body length ( J:211773 )
IMPC - TCP

hematopoietic system

skeleton




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory