All Phenotypes Smg6<tm1.1Zqw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smg6^tm1.1Zqw
targeted mutation 1.1, Zhao-Qi Wang
MGI:5763144

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Smg6^tm1.1Zqw/Smg6^tm1.1Zqw Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5763151

Allelic Composition	Smg6^tm1.1Zqw/Smg6^tm1.1Zqw Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
Smg6^tm1.1Zqw mutation (0 available); any Smg6 mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:222980 )

N	• tamoxifen-treated embryonic stem cells exhibit normal viability and self-renewal

abnormal cell morphology ( J:222980 )

• tamoxifen-treated embryonic stem cells fail to differentiate in vitro and in vivo

abnormal telomere morphology ( J:222980 )

• tamoxifen-treated embryonic stem cells and embryonic fibroblasts exhibit defective telomere maintenance

abnormal cell physiology ( J:222980 )

• tamoxifen-treated embryonic stem cells exhibit nonsense-mediated mRNA decay

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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