Phenotypes associated with this allele

• Allele Symbol: Supt4a^tm1Yty
• Allele Name: targeted mutation 1, Yu-Ting Yan
• Allele ID: MGI:5763055
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Supt4a^tm1Yty/Supt4a^tm1Yty	involves: 129S6/SvEvTac * C57BL/6	MGI:5763067
ht2	Supt4a^tm1Yty/Supt4a^+	involves: 129S6/SvEvTac * C57BL/6	MGI:5763068
cx3	Supt4a^tm1Yty/Supt4a^+ Tg(HDexon1)62Gpb/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5763069

Genotype
MGI:5763067

hm1

• Allelic Composition: Supt4a^tm1Yty/Supt4a^tm1Yty
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:224237 )

• mice die at E7.5

Genotype
MGI:5763068

ht2

• Allelic Composition: Supt4a^tm1Yty/Supt4a⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

mortality/aging ( J:224237 )

N • mice exhibit normal lifespan for at least 18 months

behavior/neurological

behavior/neurological phenotype ( J:224237 )

N • mice exhibit normal motor function for at least 18 months

Genotype
MGI:5763069

cx3

• Allelic Composition: Supt4a^tm1Yty/Supt4a⁺; Tg(HDexon1)62Gpb/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

mortality/aging

premature death ( J:224237 )

• mice exhibit premature death compared with wild-type mice but improved survival compared with Tg(HDexon1)62Gpb mice

behavior/neurological

impaired coordination ( J:224237 )

• impaired performance on a rotarod is delayed until 13 weeks of age compared with 10 weeks as in Tg(HDexon1)62Gpb mice

• improved beam walking compared with Tg(HDexon1)62Gpb mice

growth/size/body

decreased body weight ( J:224237 )

• as in Tg(HDexon1)62Gpb mice