Phenotypes associated with this allele

• Allele Symbol: Apoc2^em1Arem
• Allele Name: endonuclease-mediated mutation 1, Alan Remaley
• Allele ID: MGI:5763016
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoc2^em1Arem/Apoc2^em1Arem	involves: C57BL/6 * FVB/NJ	MGI:5763018
ht2	Apoc2^em1Arem/Apoc2^+	involves: C57BL/6 * FVB/NJ	MGI:5763019

Genotype
MGI:5763018

hm1

• Allelic Composition: Apoc2^em1Arem/Apoc2^em1Arem
• Genetic Background: involves: C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:227332 )

• visibly turbid plasma

abnormal circulating cholesterol level ( J:227332 )

• higher free cholesterol in plasma but decreased in esterified cholesterol

decreased circulating HDL cholesterol level ( J:227332 )

increased circulating triglyceride level ( J:227332 )

increased circulating VLDL triglyceride level ( J:227332 )

abnormal lipoprotein level ( J:227332 )

• apoA-I from HDL to VLDL and decreased levels of HDL-C

• apoE, apoB, apoM, apoJ and histidine-rich glycoprotein (HRG) are decreased on VLDL/Chylos

Genotype
MGI:5763019

ht2

• Allelic Composition: Apoc2^em1Arem/Apoc2⁺
• Genetic Background: involves: C57BL/6 * FVB/NJ

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:227332 )

• slightly

increased circulating triglyceride level ( J:227332 )

• modest

increased circulating VLDL triglyceride level ( J:227332 )

• intermediate phenotype