All Phenotypes Bag3<tm1c(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen Tg(Myhca-cre)1Abel/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N	MGI:6107910
cn2	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myhca-cre)1Abel/0	involves: C57BL/6 * C57BL/6N * C57BL/6NCrlj * DBA/2 * FVB/N	MGI:6107905
cn3	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(Myhca-cre)1Abel/0	involves: C57BL/6N * FVB/N	MGI:6107901

Allelic Composition	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen Tg(Myhca-cre)1Abel/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
Cell Lines	HEPD0556_7_B06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag3^tm1.1Chen mutation (0 available); any Bag3 mutation (31 available)
Bag3^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Bag3 mutation (31 available)
Tg(Myhca-cre)1Abel mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac enlargement in Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen Tg(Myhca-cre)1Abel/0 mice at 6 months of age

cardiovascular system

enlarged heart ( J:246352 )

• cardiac enlargement

increased heart weight ( J:246352 )

• heart weight to body weight and heart weight to tibia length ratios are increased at 5 months of age

dilated cardiomyopathy ( J:246352 )

decreased cardiac muscle contractility ( J:246352 )

• diminished systolic function

abnormal heart echocardiography feature ( J:246352 )

• diminished systolic function with mice showing reduced fractional shortening, increased left ventricle internal diameter at end diastole and increased left ventricle internal diameter at end systole

homeostasis/metabolism

impaired autophagy ( J:246352 )

• hearts exhibit impaired autophagic flux

cellular

impaired autophagy ( J:246352 )

• hearts exhibit impaired autophagic flux

muscle

dilated cardiomyopathy ( J:246352 )

decreased cardiac muscle contractility ( J:246352 )

• diminished systolic function

growth/size/body

enlarged heart ( J:246352 )

• cardiac enlargement

increased heart weight ( J:246352 )

• heart weight to body weight and heart weight to tibia length ratios are increased at 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1HH		DOID:0110448	OMIM:613881	J:246352

Allelic Composition	Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Myhca-cre)1Abel/0
Genetic Background	involves: C57BL/6 * C57BL/6N * C57BL/6NCrlj * DBA/2 * FVB/N
Cell Lines	HEPD0556_7_B06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag3^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Bag3 mutation (31 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
Tg(Myhca-cre)1Abel mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:246352 )

• after 18 hours of starvation, mice exhibit a reduction in LC3-GFP accumulation in the myocardium, indicating suppressed autophagic flux in hearts

homeostasis/metabolism

impaired autophagy ( J:246352 )

• after 18 hours of starvation, mice exhibit a reduction in LC3-GFP accumulation in the myocardium, indicating suppressed autophagic flux in hearts

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dilated cardiomyopathy in Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(Myhca-cre)1Abel/0 mice

homeostasis/metabolism

abnormal autophagosome formation ( J:246352 )

• neonatal cardiomyocytes exhibit suppression of autophagosome formation following bafilomycin-A1 and chloroquine treatment

impaired autophagy ( J:246352 )

• neonatal cardiomyocytes exhibit suppression of autophagosome formation following bafilomycin-A1 and chloroquine treatment indicating impaired autophagy

mortality/aging

premature death ( J:246352 )

• mice are susceptible to premature death, with only 9% of mice surviving past 20 months of age

cardiovascular system

enlarged heart ( J:246352 )

• cardiac enlargement in 6 month old mice

increased heart weight ( J:246352 )

• heart weight to body weight and heart weight to tibia length ratios are increased at 4 months of age

cardiac fibrosis ( J:246352 )

• severe fibrosis in surviving 6 month old mice

dilated cardiomyopathy ( J:246352 )

decreased cardiac muscle contractility ( J:246352 )

• peak rate of pressure rise and peak rate of pressure decline are reduced as early as 10 weeks of age, indicating early impairment of cardiac contractile function

• single myocyte contraction induced by field stimulation is reduced

• however, the profiles of induced calcium transients, including amplitude and tau, are not affected

abnormal fetal cardiomyocyte physiology ( J:246352 )

• neonatal cardiomyocytes exhibit suppression of autophagosome formation following bafilomycin-A1 and chloroquine treatment indicating impaired autophagy

abnormal heart echocardiography feature ( J:246352 )

• echocardiography shows an age-dependent decrease in left ventricular systolic function, and left ventricle chamber dilation as evidenced by an increase in end-diastolic left ventricle internal diameter and end-systolic left ventricle internal diameter

abnormal myocardial fiber physiology ( J:246352 )

• single myocyte contraction induced by field stimulation is reduced

congestive heart failure ( J:246352 )

cellular

abnormal autophagosome formation ( J:246352 )

• neonatal cardiomyocytes exhibit suppression of autophagosome formation following bafilomycin-A1 and chloroquine treatment

impaired autophagy ( J:246352 )

• neonatal cardiomyocytes exhibit suppression of autophagosome formation following bafilomycin-A1 and chloroquine treatment indicating impaired autophagy

muscle

dilated cardiomyopathy ( J:246352 )

decreased cardiac muscle contractility ( J:246352 )

• peak rate of pressure rise and peak rate of pressure decline are reduced as early as 10 weeks of age, indicating early impairment of cardiac contractile function

• single myocyte contraction induced by field stimulation is reduced

• however, the profiles of induced calcium transients, including amplitude and tau, are not affected

growth/size/body

enlarged heart ( J:246352 )

• cardiac enlargement in 6 month old mice

increased heart weight ( J:246352 )

• heart weight to body weight and heart weight to tibia length ratios are increased at 4 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1HH		DOID:0110448	OMIM:613881	J:246352

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23