All Phenotypes Col1a1<tm19(tetO-GFP,-cas9*)Slowe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col1a1^{tm19(tetO-GFP,-cas9*)Slowe}
targeted mutation 19, Scott Lowe
MGI:5755842

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Col1a1^{tm19(tetO-GFP,-cas9*)Slowe}/Col1a1⁺	involves: 129S4/SvJae * C57BL/6	MGI:5755880
cn2	Col1a1^{tm19(tetO-GFP,-cas9)Slowe}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJae * C57BL/6	MGI:5755879

Allelic Composition	Col1a1^{tm19(tetO-GFP,-cas9*)Slowe}/Col1a1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm19(tetO-GFP,-cas9*)Slowe} mutation (0 available); any Col1a1 mutation (160 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:222595 )

N	• doxycycline-treated mice exhibit normal crypt proliferation, differentiation and Paneth cell production

Allelic Composition	Col1a1^{tm19(tetO-GFP,-cas9)Slowe}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTAM2)Jae}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm19(tetO-GFP,-cas9*)Slowe} mutation (0 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

ectopic Paneth cells ( J:222595 )

• increased in doxycycline-treated mice

abnormal small intestinal crypt cell physiology ( J:222595 )

• doxycycline-treated mice exhibit dramatic hyper-proliferation and crypt expansion, blocked differentiation and ectopic Paneth cell production compared with control mice

abnormal small intestinal crypt cell proliferation ( J:222595 )

• increased in doxycycline-treated mice

cellular

abnormal small intestinal crypt cell proliferation ( J:222595 )

• increased in doxycycline-treated mice

endocrine/exocrine glands

ectopic Paneth cells ( J:222595 )

• increased in doxycycline-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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