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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp1r12aem1Sfsh
endonuclease-mediated mutation 1, Steven A Fisher
MGI:5755518
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp1r12aem1Sfsh/Ppp1r12a+
Tg(Myh11-icre/ERT2)1Soff/0 		involves: C57BL/6J * FVB/N MGI:5776052


Genotype
MGI:5776052
cn1
Allelic
Composition		 Ppp1r12aem1Sfsh/Ppp1r12a+
Tg(Myh11-icre/ERT2)1Soff/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r12aem1Sfsh mutation (1 available); any Ppp1r12a mutation (64 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel physiology ( J:230106 )
• tamoxifen-treated mice exhibit a 5-fold increase in sensitivity to 8-Br-cGMP under calcium clamp and increased maximal relaxation in mesenteric arteries compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory