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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sprtntm1.1Yjm
targeted mutation 1.1, Yuichi J Machida
MGI:5752652
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Sprtntm1.1Yjm/Sprtntm1.1Yjm 		involves: 129S/SvEv * 129S4/SvJae MGI:6515755


Genotype
MGI:6515755
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Sprtntm1.1Yjm/Sprtntm1.1Yjm
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
Sprtntm1.1Yjm mutation (0 available); any Sprtn mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:297179 )
• failure to repair DNA-protein crosslinks (DPCs) in mouse embryo fibroblasts (MEFs)
• increased accumulation of camptothecin (CPT)-induced topoisomerase 1 cleavage complex (Top1cc) foci in MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory