Phenotypes associated with this allele

• Allele Symbol: Pk27053
• Allele Name: pyruvate kinase activity mutant 27053
• Allele ID: MGI:5752521
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pk27053/Pk27053	Not Specified	MGI:5752531
ht2	Pk27053/Pk27053^+	Not Specified	MGI:5752529

Genotype
MGI:5752531

hm1

• Allelic Composition: Pk27053/Pk27053
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased pyruvate kinase activity ( J:82809 )

• liver pyruvate kinase activity is elevated in mice homozygous for this mutation.

• erythrocyte pyruvate kinase activity in homozygous mutant mice is elevated up to 240% that of wild-type mice.

• pyruvate kinase activity in brain, heart, kidney, lung, muscle, and spleen of mutant mice is similar to that observed in these organs from wild-type mice.

Genotype
MGI:5752529

ht2

• Allelic Composition: Pk27053/Pk27053⁺
• Genetic Background: Not Specified

homeostasis/metabolism

increased pyruvate kinase activity ( J:82809 )

• erythrocyte pyruvate kinase activity in heterozygous mutant mice is elevated up to 160% that of wild-type mice.

• liver pyruvate kinase activity is elevated in mice heterozygous for this mutation.

• pyruvate kinase activity in brain, heart, kidney, lung, muscle, and spleen of mutant mice is similar to that observed in these organs from wild-type mice.