Phenotypes associated with this allele

• Allele Symbol: Prdm13^tm1.2Tfur
• Allele Name: targeted mutation 1.2, Takahisa Furukawa
• Allele ID: MGI:5752207
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm13^tm1.2Tfur/Prdm13^tm1.2Tfur	involves: C57BL/6 * C57BL/6J * C57BL/6N	MGI:5780205

Genotype
MGI:5780205

hm1

• Allelic Composition: Prdm13^tm1.2Tfur/Prdm13^tm1.2Tfur
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased amacrine cell number ( J:222242 )

• ~50% decrease in amacrine cell number at P14, with a specific reduction in GABAergic and glycinergic amacrine cells but normal numbers of amacrine cells containing other neurotransmitters, such as glutamate, acetylcholine, and dopamine

• ~30% reduction in Calbindin- and Calretinin-positive amacrine cells that project to the S2/S3 border in the IPL

• however, no significant increase in retinal apoptosis at P3 or P14

thin retina inner nuclear layer ( J:222242 )

• significantly thinner INL at P14 and at 5 months of age

• significantly reduced INL + IPL (inner plexiform layer) thickness at P14

• however, normal outer nuclear layer (ONL) thickness at P14 and at 5 months of age

abnormal retina inner plexiform layer morphology ( J:222242 )

• loss of the S2/S3 border neurite bundle labeled by anti-Calbindin or anti-Calretinin antibodies in the IPL at P14

thin retina inner plexiform layer ( J:222242 )

• significantly thinner IPL at 5 months but not at P14

abnormal visual contrast sensitivity ( J:222242 )

• abnormally increased contrast sensitivities in optokinetic responses at 2 months of age

behavior/neurological

abnormal optokinetic reflex ( J:222242 )

• abnormally increased spatial, temporal, and contrast sensitivities in optokinetic responses at 2 months of age

nervous system

decreased amacrine cell number ( J:222242 )

• ~50% decrease in amacrine cell number at P14, with a specific reduction in GABAergic and glycinergic amacrine cells but normal numbers of amacrine cells containing other neurotransmitters, such as glutamate, acetylcholine, and dopamine

• ~30% reduction in Calbindin- and Calretinin-positive amacrine cells that project to the S2/S3 border in the IPL

• however, no significant increase in retinal apoptosis at P3 or P14