Phenotypes associated with this allele

• Allele Symbol: Sars1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5751876
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sars1^tm1.1(KOMP)Vlcg/Sars1^tm1.1(KOMP)Vlcg	B6N(Cg)-Sars1^tm1.1(KOMP)Vlcg/2J	MGI:6376229
hm2	Sars1^tm1.1(KOMP)Vlcg/Sars1^tm1.1(KOMP)Vlcg	C57BL/6N-Sars1^tm1.1(KOMP)Vlcg/J	MGI:6263420
ht3	Sars1^tm1.1(KOMP)Vlcg/Sars1^+	C57BL/6N-Sars1^tm1.1(KOMP)Vlcg/J	MGI:6263419

Genotype
MGI:6376229

hm1

• Allelic Composition: Sars1^{tm1.1(KOMP)Vlcg}/Sars1^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Sars1^{tm1.1(KOMP)Vlcg}/2J
• Cell Lines: 18995A-G10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at lower Mendelian ratios at E3.5 (11% versus expected 25%) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

embryo

failure of blastocyst formation ( J:279207 )

• embryos fail to reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in culture, embryos fail to hatch from the zona pellucida with apparent cell death, never reaching a morphological blastocyst stage

abnormal morula morphology ( J:279207 )

• morulas recovered at E3.5 appear to be dying

cellular

increased cell death ( J:279207 )

• morulas recovered at E3.5 appear to be dying

• embryos show apparent cell death after 3 days in culture

Genotype
MGI:6263420

hm2

• Allelic Composition: Sars1^{tm1.1(KOMP)Vlcg}/Sars1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Sars1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18995A-G10

Data Sources

IMPC Data for Sars1

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6263419

ht3

• Allelic Composition: Sars1^{tm1.1(KOMP)Vlcg}/Sars1⁺
• Genetic Background: C57BL/6N-Sars1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18995A-G10

Data Sources

IMPC Data for Sars1

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - JAX

pigmentation

abnormal iris pigmentation ( J:211773 )

IMPC - JAX

vision/eye

abnormal iris pigmentation ( J:211773 )

IMPC - JAX