Phenotypes associated with this allele

• Allele Symbol: Dpysl3^tm1Gosh
• Allele Name: targeted mutation 1, Yoshio Goshima
• Allele ID: MGI:5751828
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dpysl3^tm1Gosh/Dpysl3^tm1Gosh Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj	MGI:5751847
cx2	Dpysl3^tm1Gosh/Dpysl3^+ Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj	MGI:5751849

Genotype
MGI:5751847

cx1

• Allelic Composition: Dpysl3^tm1Gosh/Dpysl3^tm1Gosh; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus pyramidal cell morphology ( J:226894 )

• CA1 pyramidal neurons bifurcate at the stratum pyramidale layer

decreased hippocampus pyramidal cell length ( J:226894 )

• in CA1 pyramidal neurons

increased hippocampus pyramidal cell number ( J:226894 )

• of type III CA1 pyramidal neurons

abnormal dendrite morphology ( J:226894 )

• cultured hippocampal neurons exhibit increased number of branching points compared with wild-type neurons

• neither number of branching points or total length is changed by Sema3A treatment unlike in wild-type cells

• however, dendrite length is normal

Genotype
MGI:5751849

cx2

• Allelic Composition: Dpysl3^tm1Gosh/Dpysl3⁺; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA * CBA/JNCrlj

nervous system

increased hippocampus pyramidal cell number ( J:226894 )

• type III CA1 pyramidal neurons