Analysis Tools
behavior/neurological
|
• mice exhibit an increased duration of immobility in tail suspension test; treatment with anti-depressant imipramine decreases duration of immobility
• however, performance in forced swim and sucrose intake tests is similar to wild-type
|
|
• under constant light, behavioral period is longer than wild-type Tg(PER3)L474Ljp mice
|
|
• under 4 hr light/20 hr dark mice exhibit a 4 hour phase delay in activity onset and offset time as compared to all controls
|
|
• mice spend more time awake in dark phase relative to wild-type mice
• however, sleep depth and homeostasis is not altered and, under constant dark, sleep amount is not altered
|
|
• mice exhibit less non rapid eye movement (NREM) sleep in dark phase
|
|
• mice exhibit less rapid eye movement (REM) sleep in light phase
• shorter average length of REM sleep episodes in both light and dark phases
|
