Phenotypes associated with this allele

• Allele Symbol: Mrgprb2^em1Xzd
• Allele Name: endonuclease-mediated mutation 1, Xinzhong Dong
• Allele ID: MGI:5749280
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrgprb2^em1Xzd/Mrgprb2^em1Xzd	C57BL/6-Mrgprb2^em1Xzd	MGI:5749369

Genotype
MGI:5749369

hm1

• Allelic Composition: Mrgprb2^em1Xzd/Mrgprb2^em1Xzd
• Genetic Background: C57BL/6-Mrgprb2^em1Xzd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:219209 )

N • mice exhibit normal mast cell numbers

decreased mast cell degranulation ( J:219209 )

• following 48/80-induction, mast cell activation and histamine release in the trachea and skin are abolished compared with wild-type cells

decreased inflammatory response ( J:219209 )

• 48/80-treated mice fail to exhibit tracheal contraction and hindpaw inflammation (extravasation and swelling) compared with wild-type mice

• however, mice exhibit normal responsiveness to anti-IgE antibodies and endothelin

hematopoietic system

hematopoietic system phenotype ( J:219209 )

N • mice exhibit normal mast cell numbers

decreased mast cell degranulation ( J:219209 )

• following 48/80-induction, mast cell activation and histamine release in the trachea and skin are abolished compared with wild-type cells

cellular

decreased mast cell degranulation ( J:219209 )

• following 48/80-induction, mast cell activation and histamine release in the trachea and skin are abolished compared with wild-type cells