Phenotypes associated with this allele

• Allele Symbol: Lef1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5708280
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lef1^tm1.1(KOMP)Vlcg/Lef1^tm1.1(KOMP)Vlcg	C57BL/6N-Lef1^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6408483
hm2	Lef1^tm1.1(KOMP)Vlcg/Lef1^tm1.1(KOMP)Vlcg	C57BL/6N-Lef1^tm1.1(KOMP)Vlcg/Ucd	MGI:6262794
ht3	Lef1^tm1.1(KOMP)Vlcg/Lef1^+	C57BL/6N-Lef1^tm1.1(KOMP)Vlcg/Ucd	MGI:6262793

Genotype
MGI:6408483

hm1

• Allelic Composition: Lef1^{tm1.1(KOMP)Vlcg}/Lef1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Lef1^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 18886A-E9

Data Sources

IMPC Data for Lef1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - TCP

Genotype
MGI:6262794

hm2

• Allelic Composition: Lef1^{tm1.1(KOMP)Vlcg}/Lef1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Lef1^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 18886A-E9

Data Sources

IMPC Data for Lef1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6262793

ht3

• Allelic Composition: Lef1^{tm1.1(KOMP)Vlcg}/Lef1⁺
• Genetic Background: C57BL/6N-Lef1^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 18886A-E9

Data Sources

IMPC Data for Lef1

cardiovascular system

abnormal heart morphology ( J:211773 )

♀

IMPC - UCD

enlarged heart ( J:211773 )

♀

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♀

IMPC - UCD

hematopoietic system

increased monocyte cell number ( J:211773 )

♂

IMPC - UCD

immune system

increased monocyte cell number ( J:211773 )

♂

IMPC - UCD

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - UCD