Phenotypes associated with this allele

• Allele Symbol: Lrrc8a^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5708254
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrc8a^tm1.1(KOMP)Vlcg/Lrrc8a^tm1.1(KOMP)Vlcg	C57BL/6N-Lrrc8a^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6325151
hm2	Lrrc8a^tm1.1(KOMP)Vlcg/Lrrc8a^tm1.1(KOMP)Vlcg	C57BL/6N-Lrrc8a^tm1.1(KOMP)Vlcg/Ucd	MGI:6262825
ht3	Lrrc8a^tm1.1(KOMP)Vlcg/Lrrc8a^+	C57BL/6N-Lrrc8a^tm1.1(KOMP)Vlcg/Ucd	MGI:6262824

Genotype
MGI:6325151

hm1

• Allelic Composition: Lrrc8a^{tm1.1(KOMP)Vlcg}/Lrrc8a^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Lrrc8a^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 12378A-F3

Data Sources

IMPC Data for Lrrc8a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - TCP

embryo

abnormal embryo size ( J:211773 )

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - TCP

homeostasis/metabolism

edema ( J:211773 )

IMPC - TCP

vision/eye

anophthalmia ( J:211773 )

IMPC - TCP

Genotype
MGI:6262825

hm2

• Allelic Composition: Lrrc8a^{tm1.1(KOMP)Vlcg}/Lrrc8a^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Lrrc8a^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 12378A-F3

Data Sources

IMPC Data for Lrrc8a

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:6262824

ht3

• Allelic Composition: Lrrc8a^{tm1.1(KOMP)Vlcg}/Lrrc8a⁺
• Genetic Background: C57BL/6N-Lrrc8a^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 12378A-F3

Data Sources

IMPC Data for Lrrc8a

growth/size/body

enlarged lung ( J:211773 )

♀

IMPC - UCD

respiratory system

abnormal lung morphology ( J:211773 )

♀

IMPC - UCD

enlarged lung ( J:211773 )

♀

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD