About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-Q10tm1.1(KOMP)Mbp
targeted mutation 1.1, Mouse Biology Program, UC Davis
MGI:5707442
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2-Q10tm1.1(KOMP)Mbp/H2-Q10tm1.1(KOMP)Mbp C57BL/6NCrl-H2-Q10tm1.1(KOMP)Mbp/MbpMmucd MGI:7551130
hm2
 		H2-Q10tm1.1(KOMP)Mbp/H2-Q10tm1.1(KOMP)Mbp involves: C57BL/6 * C57BL/6N MGI:6467004


Genotype
MGI:7551130
hm1
Allelic
Composition		 H2-Q10tm1.1(KOMP)Mbp/H2-Q10tm1.1(KOMP)Mbp
Genetic
Background		 C57BL/6NCrl-H2-Q10tm1.1(KOMP)Mbp/MbpMmucd
Cell Lines DEPD00574_4_B02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Q10tm1.1(KOMP)Mbp mutation (1 available); any H2-Q10 mutation (17 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
cystolithiasis ( J:211773 )
IMPC - UCD




Genotype
MGI:6467004
hm2
Allelic
Composition		 H2-Q10tm1.1(KOMP)Mbp/H2-Q10tm1.1(KOMP)Mbp
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Q10tm1.1(KOMP)Mbp mutation (1 available); any H2-Q10 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased NK cell number ( J:294888 )
• reduced conventional NK (cNK) cell number and percentage in liver
• reduced CD27-/CD11b+ conventional NK (cNK) cell number and percentage in liver
• reduced CD27+/CD11b+ conventional NK (cNK) cell number in liver
• normal conventional NK (cNK) cell number and percentage in spleen
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased immature NK cell number ( J:294888 )
• reduced CD94+/Ly49C- conventional NK (cNK) cell number and frequency in liver
decreased mature NK cell number ( J:294888 )
• reduced CD94-/Ly49C+ conventional NK (cNK) cell number and frequency in liver
increased NK cell number ( J:294888 )
• increased CD27+/CD11b- conventional NK (cNK) cell percentage in liver
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased gamma-delta T cell number ( J:294888 )
• reduced CD8a+/CD8a+ cell number and percentage in liver
• normal CD8a+/CD8a+ cell number and percentage in spleen

immune system
decreased NK cell number ( J:294888 )
• reduced conventional NK (cNK) cell number and percentage in liver
• reduced CD27-/CD11b+ conventional NK (cNK) cell number and percentage in liver
• reduced CD27+/CD11b+ conventional NK (cNK) cell number in liver
• normal conventional NK (cNK) cell number and percentage in spleen
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased immature NK cell number ( J:294888 )
• reduced CD94+/Ly49C- conventional NK (cNK) cell number and frequency in liver
decreased mature NK cell number ( J:294888 )
• reduced CD94-/Ly49C+ conventional NK (cNK) cell number and frequency in liver
increased NK cell number ( J:294888 )
• increased CD27+/CD11b- conventional NK (cNK) cell percentage in liver
• normal KLRG1+, CD96+ and TIGIT+ conventional NK (cNK) cell number in liver
decreased gamma-delta T cell number ( J:294888 )
• reduced CD8a+/CD8a+ cell number and percentage in liver
• normal CD8a+/CD8a+ cell number and percentage in spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory