Phenotypes associated with this allele

• Allele Symbol: Clpx^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5707301
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clpx^tm1.1(KOMP)Vlcg/Clpx^tm1.1(KOMP)Vlcg	B6N(Cg)-Clpx^tm1.1(KOMP)Vlcg/J	MGI:6262162

Genotype
MGI:6262162

hm1

• Allelic Composition: Clpx^{tm1.1(KOMP)Vlcg}/Clpx^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Clpx^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 14944A-C8

Data Sources

IMPC Data for Clpx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

failure to gastrulate ( J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 , J:279207 )

IMPC - JAX (J:211773)

MGI

• homozygous embryos are recovered at lower than expected Mendelian ratios at E7.5 (17% versus 25%) and arrest prior to gastrulation (J:279207)

embryonic lethality, complete penetrance ( J:279207 )

• no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX