Phenotypes associated with this allele

• Allele Symbol: Ankrd1^tm1.2Jmda
• Allele Name: targeted mutation 1.2, Jeffrey M Davidson
• Allele ID: MGI:5707279
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankrd1^tm1.2Jmda/Ankrd1^tm1.2Jmda	B6.129S6(Cg)-Ankrd1^tm1.2Jmda	MGI:5708103
hm2	Ankrd1^tm1.2Jmda/Ankrd1^tm1.2Jmda	involves: 129S6/SvEvTac * C57BL/6J	MGI:5708100
ht3	Ankrd1^tm1.2Jmda/Ankrd1^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:5708101

Genotype
MGI:5708103

hm1

• Allelic Composition: Ankrd1^tm1.2Jmda/Ankrd1^tm1.2Jmda
• Genetic Background: B6.129S6(Cg)-Ankrd1^tm1.2Jmda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal postnatal growth ( J:218253 )

• growth diminishing effect

homeostasis/metabolism

delayed wound healing ( J:218253 )

• retarded until at least 21 days after injury

integument

epidermal necrosis ( J:218253 )

• increased wound skin flap necrosis

• necrosis less severe in heterozygotes

• treatment with adenovirus expressing ANKRD1 can reduce necrosis (in controls as well)

cellular

epidermal necrosis ( J:218253 )

• increased wound skin flap necrosis

• necrosis less severe in heterozygotes

• treatment with adenovirus expressing ANKRD1 can reduce necrosis (in controls as well)

Genotype
MGI:5708100

hm2

• Allelic Composition: Ankrd1^tm1.2Jmda/Ankrd1^tm1.2Jmda
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

reproductive system

reproductive system phenotype ( J:218253 )

N • normal litter size and Mendelian ratios

homeostasis/metabolism

delayed wound healing ( J:218253 )

• openings contract more slowly

• delay is particularly significant between days 6 and 8 after injury

impaired wound healing ( J:218253 )

• mildly impaired

• thinner granulation tissues and wider wound gap

growth/size/body

growth/size/body region phenotype ( J:218253 )

N • body weight and organ weights of spleen, liver, kidney, brain, and skeletal muscle all normal

cardiovascular system

abnormal heart ventricles weight ( J:218253 )

• significantly increased in both sexes

Genotype
MGI:5708101

ht3

• Allelic Composition: Ankrd1^tm1.2Jmda/Ankrd1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

homeostasis/metabolism

impaired wound healing ( J:218253 )

• mildly impaired

cardiovascular system

abnormal heart ventricles weight ( J:218253 )

♀ • females only show a moderate increase