All Phenotypes Lonp1<tm1Otin> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lonp1^tm1Otin
targeted mutation 1, Carlos Lopez-Otin
MGI:5707160

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lonp1^tm1Otin/Lonp1^tm1Otin	Not Specified	MGI:5707192
ht2	Lonp1^tm1Otin/Lonp1⁺	Not Specified	MGI:5707193

Allelic Composition	Lonp1^tm1Otin/Lonp1^tm1Otin
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lonp1^tm1Otin mutation (0 available); any Lonp1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, incomplete penetrance ( J:221992 )

• though present in Mendelian ratios at E3.5, only 1 mouse is present at E8.5 and no mice are present at E9.5

embryo

embryonic growth retardation ( J:221992 )

• at E7.5 and E8.5

• however, mice are normal size at E5.5 and E6.5

decreased embryo size ( J:221992 )

• at E7.5 and E8.5

• however, mice are normal size at E5.5 and E6.5

abnormal inner cell mass morphology ( J:221992 )

• small

abnormal trophoblast giant cell morphology ( J:221992 )

• small

cellular

decreased mitochondrial DNA content ( J:221992 )

• at E7.5

growth/size/body

embryonic growth retardation ( J:221992 )

• at E7.5 and E8.5

• however, mice are normal size at E5.5 and E6.5

decreased embryo size ( J:221992 )

• at E7.5 and E8.5

• however, mice are normal size at E5.5 and E6.5

Allelic Composition	Lonp1^tm1Otin/Lonp1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lonp1^tm1Otin mutation (0 available); any Lonp1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:221992 )

• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice

• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:221992 )

• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice

• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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