About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Helz2tm1Tesa
targeted mutation 1, Tetsurou Satoh
MGI:5707023
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Helz2tm1Tesa/Helz2tm1Tesa B6.Cg-Helz2tm1Tesa MGI:5707501
cx2
Helz2tm1Tesa/Helz2tm1Tesa
Leprdb/Leprdb
involves: C57BL/6 * C57BLKS/J MGI:5707502


Genotype
MGI:5707501
hm1
Allelic
Composition
Helz2tm1Tesa/Helz2tm1Tesa
Genetic
Background
B6.Cg-Helz2tm1Tesa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Helz2tm1Tesa mutation (0 available); any Helz2 mutation (140 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal food intake on a normal diet
• normal locomotor activity on a normal diet

growth/size/body
N
• body weight gain is normal on a normal diet
• weight gain is less than for controls on a high fat diet

homeostasis/metabolism
N
• normal fasting blood glucose on a normal diet
• insulin levels are normal on a normal diet
• leptin levels normal on a normal diet
• normal adiponectin levels on a normal diet
• sustained hyperleptinemia on a high fat diet
• relative to controls on a high fat diet
• relative to controls on a high fat diet
• less fat deposition than controls on a high fat diet
• triglyceride levels are reduced in the liver on a high fat diet

liver/biliary system
• triglyceride levels are reduced in the liver on a high fat diet
• liver enlargement is reduced relative to controls on a high fat diet
• ameliorated relative to controls on a high fat diet




Genotype
MGI:5707502
cx2
Allelic
Composition
Helz2tm1Tesa/Helz2tm1Tesa
Leprdb/Leprdb
Genetic
Background
involves: C57BL/6 * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Helz2tm1Tesa mutation (0 available); any Helz2 mutation (140 available)
Leprdb mutation (17 available); any Lepr mutation (121 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice have no protection against obesity on a high fat diet





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory