All Phenotypes Opn5<tm1.1Yau> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Opn5^tm1.1Yau
targeted mutation 1.1, King-Wai Yau
MGI:5706751

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Opn5^tm1.1Yau/Opn5^tm1.1Yau	involves: 129	MGI:5897198
cx2	Opn5^tm1.1Lan/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * FVB/N	MGI:5897197
cx3	Opn5^tm1.1Yau/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺	involves: 129S6/SvEvTac	MGI:5897200

Allelic Composition	Opn5^tm1.1Yau/Opn5^tm1.1Yau
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn5^tm1.1Yau mutation (0 available); any Opn5 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circardian behavior entrainment ( J:227078 )

• mice exhibit slower reentrainment to a phase advances in the external light/dark cycles compared with wild-type mice

• however, mice exhibit normal entrainment to 12-h/12-h light/dark cycle and normal free-running periods in constant darkness

Allelic Composition	Opn5^tm1.1Lan/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn5^tm1.1Lan mutation (0 available); any Opn5 mutation (19 available)
Opn5^tm1.1Yau mutation (0 available); any Opn5 mutation (19 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:227078 )

• ex vivo corneal photoentrainment is abolished

Allelic Composition	Opn5^tm1.1Yau/Opn5^tm1.1Yau Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn5^tm1.1Yau mutation (0 available); any Opn5 mutation (19 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:227078 )

N	• mice exhibit normal retinal histology and normal optokinetic tracking reflex

abnormal eye physiology ( J:227078 )

• retinas fail to exhibit light/dark entrainment

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